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Treatment of chronic migraine with botulinum toxin type A drugs at the EMC Neurology Clinic

Migraine is one of the most common causes of chronic headaches among adults. More than 30 million Russian residents experience one or more migraine attacks per year. Every 12 months, 2.5% of these patients have episodic migraines that turn into chronic ones. 
 
Chronic migraine is a condition in which a patient experiences headaches of any intensity for more than 15 days and more than 8 episodes of migraine per month. This is an extremely serious disease that affects mostly active middle-aged people. 
 
Unfortunately, classical medical treatment of migraines is ineffective in this disease.  This leads to the abuse of drugs, the action of which is aimed at relieving migraine attacks. This, in turn, worsens the course of the disease, since the frequent use of painkillers independently causes a new type of headache – an abusive headache. 
 
Over the past decade, experts in the field of treatment of chronic headaches have conducted many studies aimed at studying botulinum toxin as a safe and effective treatment for chronic migraines.  As a result of these studies, botulinum toxin was recognized as a drug whose effectiveness and safety in the treatment of chronic migraine is considered to be the highest — Class A — significantly higher than the commonly used tricyclic antidepressants, beta blockers and most antiepileptic drugs. 
The mechanism of action of botulinum toxin as an agent aimed at preventing the occurrence of migraine attacks is associated with its ability to block the release of substances that participate in the pathological cascade that results in a headache attack.
 
Botulinum toxin is injected directly into the muscles of the head and neck, according to a specially recommended and standardized scheme. The efficiency is more than 50%. This means that after the procedure, the number and intensity of seizures decreases by more than half. The duration of the effect is on average 6 months or longer. With repeated injections, there is also a tendency to increase the duration of the effect of botulinum toxin administration. This contradicts the prevailing opinion about "getting hooked on the drug" and "gradually reducing the intervals between injections." In this situation, the key to the effectiveness of treatment is the correct selection of patients (the presence of true chronic migraine) and a high level of professionalism of the doctor who uses this technique.
 
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Tumor in the breast
I’ve had a tumor in the lower part of my right breast and a metastasis in the left lymph node removed in 2011. I then had a recurrence in the upper quadrant of the right breast. But the doctors didn’t immediately react to this, even though I told them that I was experiencing some discomfort. After this I had biopsies
under ultrasound guidance at several medical centers, but I keep getting a completely different diagnosis everywhere I go. I still haven’t received any treatment. Test results are good. The metastasis is not growing but just sitting there. They’ve suggested a mastectomy. What’s the point? I don’t want to undergo chemotherapy. I’m on a raw food diet. I don't know what to do. I wish at least one of the diagnoses was confirmed. I want to be sure that I’m getting the right treatment. Because it’s the doctors that have brought me to this situation, even though I’ve had regular screenings for the past 25 years.
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Before answering any questions regarding treatment, it is necessary to carry out a successful biopsy under ultrasound or X-ray guidance, to obtain multiple tissue samples (not cells) with subsequent histological and immunohistochemical analysis. Only then can we discuss a specific treatment plan! In any case, EMC
staff are always ready to provide advice and carry out the necessary diagnostic tests. Best regards, Irina Vassilieva — M.D, radiologist, Head of EMC Breast Clinic
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